After the multivariate model developed to build the GRS, the number of SNPs significantly associated with risk to HTN was reduced to 16 (Table 1), correspond to 10 different genes (STK39, ULK4, ADRB2, SMARCA2, PAX5, CACNB2, PLEKHA7, ITGA11, FTO and UMODL1). This evidence concerns the gene CACNB2 and hypertensive disorder.