Since GluN2B-containing NMDARs play critical roles in fear memory stability (Mamou et al., 2006), fear extinction (Dalton et al., 2012), and fear memory generalization (Asim et al., 2020), dysfunction of GluN2B-containing NMDARs may underlie the symptoms of PTSD. This evidence concerns the gene GRIN2B and post-traumatic stress disorder.