It has been found subsequently that both NMDAR inhibitors and positive allosteric modulators (PAM) may produce antidepressant-like effects in rodent models (Li et al., 2011, 2021; Pothula et al., 2021a,b), raising the question regarding the direction of GluN2B-containing NMDAR dysregulation during MDD. Here, GRIN2B is linked to major depressive disorder.