CTCF and Neurodevelopmental delay: To date, 76 CTCF variants have been described in over 100 individuals that present with variable NDD phenotypes (Iossifov et al., 2014; Deciphering Developmental Disorders Study, 2015; Bastaki et al., 2017; Willsey et al., 2017; Chen et al., 2019; Konrad et al., 2019; Squeo et al., 2020; Wang et al., 2020; Hiraide et al., 2021; Valverde de Morales et al., 2022).