MYC and lymphoma: For instance, large quantities of superoxide can be produced by Enterococcus faecalis, which will bring about double‐strand DNA damage and chromosome instability.[152] In EBV‐associated lymphoma, the virus can reprogram the genes of MYC and BCL2L11 and form a new DNA loop in which the MYC gene has closer contact with its enhancer, while BCL2L11 is blocked to contact its enhancer.