These 15 genes (HMGB1, STAT1, EGR1, NR3C1, EGFR, MAPK14, CASP3, CASP1, IL4, IL13, IKBKB, FN1) are considered to be the key genes for the anti-RA effect of EMO. The gene discussed is IKBKB; the disease is rheumatoid arthritis.