CASP3 and rheumatoid arthritis: Abnormal cell apoptosis in RA is not only related to the abnormal expression of apoptosis-related genes, but also many molecules are involved in the regulation of apoptosis, such as Fas-gene, Bcl-2 gene and some oncogene and Caspase-3, etc., (Zhu et al., 2016; Ma et al., 2021).