Furthermore, we found that several upregulated genes in those enhanced subclones, including SYT14, CREB5, and ABCA1, were associated with drug resistance and tumor proliferation in previous reports (Sheng et al., 2018; Wang et al., 2020; Oberle et al., 2022; Tong et al., 2022) (Figures 2C, 4B). The gene discussed is CREB5; the disease is neoplasm.