AKT1 and systemic lupus erythematosus: Jieduquyuziyin prescription, which contains both herbs from KF and BF formulae, has been shown to ameliorate SLE in MRL/lpr mice by inhibiting the expression of the IRAK1-NF-κB and PI3K/Akt/PGC-1α signaling pathways (Ji et al., 2020; Ji et al., 2022).