PTEN and colitis: Xiong et al. (2018) explored the function and mechanism of fortunellin in treating UC using TNBS-induced colitis rats as a model. Fortunellin alleviated the clinical signs of UC, involving excessive inflammatory symptoms and oxidative stress. Fortunellin reduced the apoptosis of epithelial cells in UC by suppressing PTEN expression. Fortunellin-caused decrease of PTEN could be neutralized by miR-374a decline. Furthermore, miR-374a knockdown in vivo partially restrained the effect of fortunellin on UC model.