In congruence with previous investigations, in this review, we discovered that natural-derived anti-colitis flavones, such as baicalein, oroxylin A, lonicerin and wogonoside notably preserved IL-1β and IL-18 production, which was linked to the suppression of NLRP3, ASC and caspase-1 in a dosage-dependent mode both in TNBS- or DSS-induced UC murine and LPS-treated THP-1 or RAW264.7 cells. This evidence concerns the gene NLRP3 and colitis.