Regarding the relationship between TQ and HIF-1α, TQ can promote the apoptosis of renal cancer cells through the HIF-1α-mediated glycolysis pathway, and its mechanism may be related to the inhibition of ubiquitination and heat shock protein 90 to reduce HIF-1α stability (Lee et al., 2019). The gene discussed is HIF1A; the disease is renal carcinoma.