The mechanism leading to the resistance, for one thing, depends on the over-activation of RIPK2-mediated NF-κB signaling pathway, and another facet is the change of tumor microenvironment caused by RIPK2-mediated immune infiltration, including CD4+ memory T-cell, dendritic cells (DCs), common lymphoid progenitors (CLPs) (Shen et al., 2022; Zhang and Wang, 2022). The gene discussed is NFKB1; the disease is neoplasm.