CXCL8 and neoplasm: As far as we know, the mechanism of IL-8 promoting tumor progression is mainly through its role as an autocrine growth factor and angiogenesis factor, and the concentration of IL-8 in the saliva of OSCC patients is higher than that of normal cohorts, which indicates that IL-8 is a potential biomarker and intervention target for OSCC (Hwang et al., 2012; Lisa Cheng et al., 2014).