To understand how RIPK2 promotes the malignant progression of CRC, a correlation analysis between RIPK2 expression level and cytokines involved in the progression of CRC hinted that patients with high RIPK2 expression also had higher secretion levels of interleukin (IL)-6, IL-8, and vascular endothelial growth factor (VEGF). This evidence concerns the gene IL6 and colorectal carcinoma.