To understand how RIPK2 promotes the malignant progression of CRC, a correlation analysis between RIPK2 expression level and cytokines involved in the progression of CRC hinted that patients with high RIPK2 expression also had higher secretion levels of interleukin (IL)-6, IL-8, and vascular endothelial growth factor (VEGF). The gene discussed is RIPK2; the disease is colorectal carcinoma.