AKT1 and hepatocellular carcinoma: For example, Shenqi Fuzheng injection can enhance the inhibitory effect of (interferon-α) IFN-α on HCC cells by decreasing the expression of vascular endothelial growth factor (VEGF) (Choa et al., 2019); Alternatively, FuzhengXiaoji prescription can be realized by improving inflammatory state and blocking Ras/MAPK and Ras/PI3K-Akt signaling pathways (Liu et al., 2022) and Jiedu granules can inhibit the migration and invasion of HCC cells by regulating Smad23-dependent and independent pathways (Liang et al., 2018).