CD8A and breast cancer: Both healthy women and breast cancer survivors exhibited statistically significant differences in the proportion of activated HLA-DR+ cells across the CD4+ T cell subsets [ANOVA: Healthy: F(3,132) = 38.674, p < 0.001, ƞ2 = 0.468, Survivors: F(3,96) = 28.862, p < 0.001, ƞ2 = 0.474] and the CD8+ T cell subsets [ANOVA: Healthy: F(3,132) = 23.513, p < 0.001, ƞ2 = 0.348, Survivors: F(3,96) = 11.842, p < 0.001, ƞ2 = 0.270] (Figures 1G, H, J, K).