Since the identification of SOD1’s role in ALS, over 30 genes have now been linked to ALS, many of which are required for autophagy, while the vast majority have been identified in large palmitoyl-proteomic studies (Chen et al., 2012; Cirulli et al., 2015; Blanc et al., 2015; Sanders et al., 2015). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.