ABHD16A, also known as Human Lymphocyte Antigen B-associated transcript 5 (BAT5), is a phosphatidylserine lipase recently identified as a novel protein depalmitoylating enzyme that has been linked to complex hereditary spastic paraplegia (HSP) (Lemire et al., 2021; Yahia et al., 2021; Miyake et al., 2022). The gene discussed is ABHD16A; the disease is hereditary spastic paraplegia.