Indeed, palmitoylation of the fALS-linked mutant form of SOD1 (G93A-SOD1) is increased in HEK293 and motor neuron cell lines, while SOD1 palmitoylation is increased in ALS patient spinal cord tissues (Antinone et al., 2013; 2017). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.