APP and Alzheimer disease: Thus far, nearly all the primary players in AD have been shown to be palmitoylated, including APP (Bhattacharyya, Barren, and Kovacs, 2013), two ɣ-secretase subunits, APH1aL and Nicastrin (Meckler et al., 2010), and β-secretase 1 (BACE1) (Benjannet et al., 2001).