This may be due the increased autophagosomes already detected in the spinal motor neurons of G93A-SOD1 mutant transgenic mouse models compared to age-matched controls (A. Li, Zhang, and Le, 2008) and increased autophagic flux in ALS patient lymphoblasts bearing the SOD1 mutation (Lastres-Becker et al., 2021). Here, SOD1 is linked to amyotrophic lateral sclerosis.