In a mouse model expressing truncated ZDHHC13 that retains the N-terminal ankyrin repeat, mice have abnormalities in hair, skin, and bone, as well as reduced survival and increased amyloidosis, indicating a role of ZDHHC13 in regulating essential functions in multiple tissue and cell types, including neurons, epithelial, and bone (Saleem et al., 2010). Here, ZDHHC13 is linked to amyloidosis.