We found that in stroke mouse models receiving domain V 7 days after ischemic event, peri-infarct excitatory synapse generation extended further into the neocortex compared to mice that did not receive domain V. Furthermore, perlecan deficient mice demonstrated less neuroblast precursor cells post-stroke than those with functional perlecan expression (Trout et al., 2021). Here, HSPG2 is linked to stroke disorder.