Finally, a GWAS including 178,691 individuals with diabetes from the CKD Genetics (CKDGen) consortium and large biobank studies identified 29 genome-wide significant loci for eGFR, including 27 novel loci for eGFR in diabetes; among these, variants near SH3BP4 and LOXL4 were not associated with eGFR in the 1,296,113 individuals without diabetes (76). This evidence concerns the gene LOXL4 and diabetes mellitus.