Altogether, 16 loci reached a p-value < 5 × 10−8, with the strongest association for a common missense mutation rs55703767 (Asp326Tyr) in the collagen type IV alpha 3 chain (COL4A3) gene, associated with a 21% lower risk of DKD (p-value = 5.3 × 10−12) (49). This evidence concerns the gene COL4A3 and diabetic kidney disease.