Genetically determined eGFR, however, was associated with 7% hypomethylation of cg19693031 within TXNIP (p-value = 0.045), as well as hypomethylation of all the CpGs identified for DKD in T2D, including three CpGs within genes: COMMD1, TMOD1, and FHOD1. The gene discussed is TXNIP; the disease is diabetic kidney disease.