Gene aggregate analysis of PAVs suggested protein kinase C isoforms (PRKCE and PRKCI) and protein tyrosine kinase 2 (PTK2) involved in DKD (105); of note, a recent GWAS on albuminuria in the general population highlighted variants in the PRKCI and demonstrated that a podocyte-specific deletion of aPKClambda/iota in mice results in severe proteinuria (82). The gene discussed is PRKCI; the disease is diabetic kidney disease.