The combined meta-analysis with 11,847 participants with T1D resulted in two loci, an intronic variant rs7583877 in AFF3, and an intergenic rs12437854 between in the RGMA and MCTP2 genes associated with kidney failure in T1D with a p-value < 5 × 10−8. The gene discussed is RGMA; the disease is type 1 diabetes mellitus.