For some variants, the effect size is markedly higher in the individuals with diabetes than in those without (e.g., UMOD, rs77924615, betaDM = −0.019, betanoDM = −0.011, Pdiff = 1.3 × 10−27; TPPP, rs4663171, betaDM = −0.011, betanoDM = −0.004; Pdiff = 2.5 × 10−9), potentially reflecting the elevated risk and accumulated risk factors for kidney complications among individuals with diabetes. The gene discussed is TPPP; the disease is diabetes mellitus.