Based on the absence of glucocorticoid drug usage and the presence of clinical symptoms such as fatigue, anorexia, and hyponatremia, etc., the patients’ serum concentrations of COR and ACTH concentrations should meet one of the following two criteria: 1. Serum concentrations of COR <5 μg/dL and ACTH <25.0 pmol/L at 8 am on two separate occasions, 2. COR <5 μg/dL and ACTH <25.0 pmol/L at 8 am once, with disappearance of COR/ACTH circadian rhythm. a This evidence concerns the gene POMC and Hyponatremia.