MGMT and glioblastoma: Certain clinical variables have been linked with outcome in glioblastoma, for example, sex-specific differences are increasingly recognized.58 In our cohort, none of the clinical variables (age, sex, MGMT methylation status and complete versus subtotal resection) showed an association with survival in univariate Cox regression analysis, except there was a trend for poorer survival with age >65 years (P = 0.078, HR = 1.64, CI 0.95–2.86; Fig. 5A).