Second, we find significant associations between TAMs (Iba1, CD68, TREM2, CD32a) and CD8+ T cells specifically in the tumour margins rather than the tumour core, suggesting TAMs may contribute to immune suppression of CD8+ T cells more strongly at the invasive front of glioblastoma and that this region warrants further exploration for stratification of patients in clinical trials. The gene discussed is TREM2; the disease is neoplasm.