We were able to identify 8103 AT8+ tau tangles, 132 465 HuD+ neurons and 299 640 DAPI+ nuclei in tissue samples from three subjects with severe Alzheimer’s disease (Braak V–VI) and 4 AT8+ tau tangles, 200 447 HuD+ neurons and 462 715 DAPI+ nuclei in tissue samples from three subjects with no significant tau pathology (Braak 0–I). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.