AKT1 and colorectal cancer: While miR-1249 is regulated by p53 and blocks colorectal cancer growth, invasion, and angiogenesis via AKT/mTOR signaling in mice (Chen et al., 2019), the link of miR-8 with AKT/mTOR signaling has only been demonstrated in Drosophila melanogaster (Hyun et al., 2009), where it is involved in the regulation of body size in response to steroids or metabolic hormones (Jin et al., 2012).