APOE and aortic atherosclerosis: Jiang S et al. explored the effect of intermittent hypobaric hypoxia (IHH) on aortic atherosclerosis in ApoE-/- mice: 8-week ApoE-/- mice were subjected to intermittent hypobaric hypoxia for 8 hours a day (simulated at 4000 m above sea level) for 8 weeks, and found that the plaque size of intermittent hypobaric hypoxia ApoE-/- mice and normoxic ApoE-/- mice was similar 8.