Comparing patients in the T2 CRS group with those in the non-T2 groups, patients in the T2 CRS group had a significantly higher incidence of comorbid asthma history, allergy status, serum eosinophil count, serum total IgE level, SNOT-22 score and serum Af-sIgG level than non-T2 CRS patients. The gene discussed is IGHE; the disease is asthma.