A prognostic model of necroptosis was constructed in HCC, and five genes, EHD1, RAC1, SFPQ, DAB2, and PABPC4, were found to be significantly associated with the prognosis, while the SFPQ gene was selected to be used for experimental validation as it had the highest prognostic value. This evidence concerns the gene PABPC4 and hepatocellular carcinoma.