IL10 and chronic recurrent multifocal osteomyelitis: Specifically, it has been demonstrated that monocytes from patients with CRMO do not express IL-10 in response to stimulation of the TLR (Toll-like receptor) 4 by LPS (lipopolysaccharides) (15) due to a defect in activation of ERK1 and ERK2 Map Kinases (18).