In addition to the molecular pathomechanisms mentioned above, gene defects have also been identified in the pathogenesis of CRMO: IL-10 expression is influenced by genetic variants within the IL-10 proximal promoter region; in particular, three promoter haplotypes (rs1800896, rs1800871, and rs1800872) affect the capacity of the IL-10 promoter to recruit the zinc finger transcription factor Sp-1 (22). The gene discussed is IL10; the disease is chronic recurrent multifocal osteomyelitis.