It has been underlined that CRMO patients show a decreased production of anti-inflammatory cytokines, such as, IL-10, IL-18 and IL-19, and an increased production of proinflammatory mediators including, among others, the aforementioned IL-1β, IL-6, IL-20 and TNF-α (13–17). This evidence concerns the gene IL10 and chronic recurrent multifocal osteomyelitis.