Tumor progression has been monitored by recording tumor images and measuring the volume change with HA‐4‐ATP‐AuNFs at a wavelength of 1200 nm.[220] Early small tumors triggered by 808 nm laser irradiation have been detected by PAA‐NRs,[221] Nd‐DTPA,[222] and RNase‐A@Au NCs.[223] AIEgens (TQ‐BPN) can identify the tumor at different progression stages by utilizing NIR‐II fluorescence microscopy. The gene discussed is RNASE1; the disease is neoplasm.