For instance, CH1055 modified with tumor‐homing peptide was empowered to diagnose transplantable and spontaneous breast tumors.[149] Thermal stable RNase A@ PbS/ZnS quantum dots were fabricated to visualize temporal changes of microvasculature remodeling in the NIR‐IIb region.[150] A heptamethine‐cyanine‐based NIR‐II fluorophore SH1 can image the heterogeneity with intrinsic targetability.[151] NIR‐II imaging shows the ability to delineate the inter‐ and intra‐tumor heterogeneity, which can be used to detail tumor histopathology. The gene discussed is RNASE1; the disease is neoplasm.