One is the nonspecific method by utilizing the enhanced permeability and retention (EPR) effect,[11] another one is molecular imaging by employing specific targeting ligands.[12, 13] The majority of cancer biomarkers have been identified as perfect targets for the diagnosis of cancer, such as epidermal growth factor receptor (EGFR), transferrin receptor, human epidermal growth factor receptor 2 (HER2), folate receptor, endothelin receptor, integrin receptor, and prostate specific membrane antigen (PSMA).[14]. Here, TFRC is linked to cancer.