Interestingly, the difference analysis of the enrichment scores of the four pathways among different clinical features showed that IFN-γ signaling and T-cytotoxic pathway were significantly highly enriched in samples with higher tumor grades (P<0.05), the other two pathways also showed this trend (Figure 1C), suggesting that the specific pathways related to TEX may become more abnormal in patients with a higher malignant degree. The gene discussed is TEX46; the disease is neoplasm.