We found that ERBB2 was significantly correlated with several pathways in HCC, including D-glutamine and D-glutamic acid metabolism, ECM degradation, EMT marker gene, p53 pathway, TGFb, mannose O-glycan biosynthesis, collagen formation, glycosylphosphatidylinositol GPI-anchored biosynthesis, cell apoptosis, angiogenesis, drug metabolism other enzymes, and mucin O-glycan biosynthesis. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.