In our overall sample, model 4 showed that those with high cystatin C had 1.2 (95% CI: 1.0, 1.5) times higher prevalence of dementia and 1.1 (95% CI: 1.0, 1.3) times higher prevalence of CIND than those with low cystatin C levels (Figure 1 and Table 2). The gene discussed is CST3; the disease is dementia.