ACE2 and infection: ACE2 is the primary receptor of SARS-CoV-2, which can form a SARS-CoV-2-ACE2 complex with SARS-CoV-2, then the membrane fusion is initiated, and the RNA is released into the cytoplasm of the host cell to complete the infection process (Wrapp et al., 2020; V’kovski et al., 2021; Jackson et al., 2022).