CAT and neoplasm: Bu and coworkers reported a redox dyshomeostasis (RDH) strategy to combat hypoxic tumor based on a nanoplatform, namely FeCysPW@ZIF‐82@CATDz (Figure 8A).[93] The catalase DNAzyme (CATDz) loaded zeolitic imidazole framework‐82 (ZIF‐82@CATDz) shell could degrade in tumor cells into Zn2+ as a cofactor for CATDz induced catalase silencing and electrophilic ligands for GSH depletion under hypoxia, both of which led to intracellular RDH and H2O2 accumulation.