HAO1 and neoplasm: GOx is identified as a crucial enzyme for tumor starvation therapy, where GOx catalyzes the glucose decomposition in TME to produce H2O2 that in turn benefits CDT.[108] Recently, Xiang and coworkers prepared a nanocomposite (LipoCaO2/Fe(OH)3‐GOx) by co‐loading GOx and CaO2/Fe(OH)3 in a biocompatible liposome (Figure 7A).[87] Acidic TME can decompose CaO2/Fe(OH)3 nanostructure to generate H2O2 and Fe3+ for triggering the Fenton reaction.