PLK1 and neoplasm: Kam et al. complexed the helical PPABLG with PEG2k‐Polythymine40, Cas9 expression plasmid, and sgRNA targeting PLK‐1 to form P‐HNPs (Figure 8).[157] In the HeLa xenograft tumors model, systemic administration of P‐HNPs loaded with Cas9 plasmid and PLK‐1 targeted sgRNA achieved 35% gene deletion and significantly suppressed the tumor growth.