Circulating circRNAs DNAJC6, TMEM56, and MBOAT2 were suggested as biomarkers for hypertrophic obstructive cardiomyopathy,16 whereas circulating circRNA_004183, circRNA_079265, and circRNA_105039 might be used for the diagnosis of congenital heart disease in children.17 This evidence concerns the gene TLCD4 and hypertrophic cardiomyopathy.