built hyaluronic acid‐decorated superparamagnetic iron oxide nanoparticles (HIONs)‐stimulated artificially reprogramming macrophages (HION@Macs), which could maintain activation of M1 macrophages due to iron ions‐induced activation of NF‐κB.[157] M1‐like macrophages can not only generate ROS, TNF‐α, and NO, for triggering tumor cell apoptosis and serve as signaling modulators to induce immune activation, but also can resist intratumoral M2‐inducing regulators and maintain activated state. The gene discussed is TNF; the disease is neoplasm.