developed M1‐like macrophage membranes‐coated PLGA‐encapsulating Fe3O4 NPs and TLR7 agonist imiquimod (R837) (PLGA‐ION‐R837@M (PIR@M)), and found that the resultant nanocarrier could efficiently target TAMs to facilitate M2‐like TAMs‐repolarization‐mediated anti‐tumor therapeutic effect and CD8+ T cells’ infiltration in mouse breast tumor. This evidence concerns the gene CD8A and neoplasm.