fabricated a type of dual‐targeting nanoparticles by linking a biocompatible M2‐targeting peptide with anti‐CSF‐1R siRNA.[56] These nanoparticles could selectively block CSF‐1‐CSF‐1R signaling of M2‐like TAMs and deplete them from the TME, resulting in a decreased tumor size (87%) and prolonged survival time of melanoma tumor‐bearing mice. The gene discussed is CSF1R; the disease is melanoma.