This process consequently results in dephosphorylation of myosin IIA, and thereby suppresses cytoskeleton rearrangement and prevents phagocytosis.[198, 201, 202] Therefore, CD47‐SIRPα interactions make a wide range of tumor cells transmit “don't eat me” signals to macrophages, thereby promotes tumor immunological escape.[196, 200, 203] To date, various agents for blocking the CD47‐SIRPα interactions have been developed, including antibodies, inhibitors, siRNAs, and analogs, etc.[17, 36]. Here, SIRPA is linked to neoplasm.