Genetic depletion of either CD24 or Siglec‐10 or blocking the CD24‐Siglec‐10 signaling with monoclonal antibodies remarkably enhanced TAMs‐mediated tumor‐engulfment in human tumor model, which suggests that M2‐like macrophages also could be manipulated to inhibit tumor progression by enhancing their tumor‐phagocytosis activity. This evidence concerns the gene CD24 and neoplasm.