TNF and neoplasm: modified JPYZ to inhibit the activity of PI3Kγ, which decreased IL‐10, increased TNF‐α and IL‐1β and ultimately reversed the M2‐like TAMs to anti‐tumor M1 phenotype in the gastric cancer through inhibiting the expression of p‐AKT, p‐IκKα/β, p‐C/EBPβ, and up‐regulating the expression of p‐NF‐κB.[148] Kaneda et al.