Therefore, PD‐L1‐PD‐1 axis was initially identified as a T cell immunocheckpoint and extensively manipulated to potentiate activation of tumor‐specific T cell immunity.[204, 205, 206] However, PD‐L1‐PD‐1 axis is also an important phagocytotic checkpoint beyond adaptive checkpoint, which can inhibit tumor‐phagocytosis capability of TAMs.[207] In this study, Gordon et al. Here, CD274 is linked to neoplasm.