Therefore, this nanoplatform dramatically reversed CD206+F4/80+CD11b+ TAMs to CD86+F4/80+CD11b+ M1 phenotype, decreased immunosuppressive FOXP3+CD4+CD25+ Treg cells, and increased anti‐tumor IFN‐γ+CD8+ T cells in B16F10 and 4T1 tumor‐bearing mice. The gene discussed is CD4; the disease is neoplasm.