designed a lipid‐coated calcium phosphonate nanoparticles‐based miRNA delivery system (CaP/miR@pMNPs), which was modified with mannose for TAMs‐targeting delivery of miR155.[134] The resultant CaP/miR@pMNPs decreased M2‐associated IL‐10, Arg1, MMP9, and vascular endothelial growth factor (VEGF) makers and increased M1‐associated IL‐12 and iNOS makers, both which resulted in great tumor suppression and prolonged survival times of tumor‐bearing mice. The gene discussed is ARG1; the disease is neoplasm.