developed a optogenetic system from conjugated polymer nanoparticles (CPNs) that encapsulated interferon heat‐shock‐promoter (HSP70) and IFN‐γ plasmid.[112] Upon near‐infrared (NIR) light irradiation, the CPNs could act as a photothermal agent to activate HSP70 for facilitating the expression of downstream IFN‐γ gene in tumor cells to promote IFN‐γ secretion, which can selectively recognize and interact with IFN‐γ receptor (IFN‐γR) expressed on surrounding M2‐like TAMs to repolarize them into tumor‐inhibiting M1 phenotype via IFN‐γ‐JAK‐STAT1 signaling pathway. This evidence concerns the gene IFNGR1 and neoplasm.