CD8A and neoplasm: extracted natural nanoparticles from cuttlefish ink (CINPs), which could reverse M2‐like TAMs to anti‐tumor M1 populations via activating mitogen‐activated protein kinase signaling pathway (Figure 6).[158] Under the NIR irradiation, CINPs could exert excellent photothermal effect and amplified TAMs‐repolarization effects and activation of tumor‐specific CD8+T cells to elicit excellent anti‐tumor responses.