CD274 and neoplasm: However, it is worthy noted that PD‐1 is also highly expressed on other anti‐tumor immune cells including B cells,[208, 209] NK cells,[210, 211] and DCs,[212, 213] as well as, overexpressed on immunosuppressive myeloid cells.[214] Therefore, the response of patients to inhibition of PD‐1‐PD‐L1 interactions may derive from action of multiple immune cells, and the clear mechanism of PD‐1 mediated blunt tumor‐phagocytosis of macrophages needs to be elucidated.