fabricated core‐shell PLGA nanoparticles loaded with catalase (Cat) and R837.[180] These PLGA‐R837@Cat nanoparticles could relieve hypoxia to reprogram immunosuppressive M2‐like TAMs toward anti‐tumor M1 phenotype due to the generation of O2 from the degradation of H2O2 catalyzed by Cat, which led to an enhanced efficacy of tumor radiotherapy. This evidence concerns the gene CAT and neoplasm.