They found that magnetite IONPs, rather than hematite IONPs, could effectively induce M2‐to‐M1 repolarization, which specifically depended on IRF5 signaling pathway mediated by TNF receptor‐associated factor 6 (TRAF6)‐ubiquitination to achieve effective inhibition of melanoma tumor growth.[155] Similarly, Jiang et al. This evidence concerns the gene TRAF6 and neoplasm.