Furthermore, intratumoral injection of CuS‐MΦ induced remarkably anti‐tumor immunity via decreasing other immunosuppressive cell subsets including Treg cells and MDSCs, increasing tumor‐infiltrating IFN‐γ‐positive CD8+ T cells and Granzyme B‐positive CD8+ T cells, as well as activating DCs. The gene discussed is IFNG; the disease is neoplasm.