designed cowpea chlorotic mottle virus‐based VLPs to deliver the type B CpG ODN1826 into TAMs (Figure 4).[89] The resultant platforms enhanced phagocytosis of CpG ODN1826 in TAMs, and thus remarkably activated TLR9 to facilitate M2‐to‐M1 repolarization with enhanced iNOS/Arg ratio in the CT26 tumor‐bearing mice, which led to obvious tumor‐inhibiting efficacy and prolonged survival time of tumor‐bearing mice. The gene discussed is TLR9; the disease is neoplasm.