Besides the direct modulation of tumor‐associated fibroblasts and ECM components, another promising method for locally recruiting effector immune cells and increasing immune cell penetration into tumor parenchyma is the site‐specific accumulation of chemokines like CXCL10 at tumor regions (Figure 2C).[95] The CXCL10‐encapsulated nanoparticles hitchhiked on the surface of red blood cells were released selectively at the metastatic lung tissue, resulting in chemokine gradients that enhanced immune cell infiltration locally. This evidence concerns the gene CXCL10 and neoplasm.