TNXB and connective tissue disorder: The TNXB gene encodes a member of the tenascin-X family of extracellular matrix glycoproteins, which is thought to function in collagen organization and extracellular matrix integrity during wound healing (Egging et al., 2007), and its deficiency or mutation has been related to the connective tissue disorder Ehlers‒Danlos syndrome (Schalkwijk et al., 2001; Merke et al., 2013).