Previous research showed that mutations in the COL4A4 gene can cause benign familial hematuria (OMIM# 141200) (Cèlia Badenas et al., 2002), which is autosomal dominant; in addition, mutations in the TNXB gene (encoding tenascin-X, an extracellular matrix protein) can cause vesicoureteral reflux type 8 (OMIM#: 615,963) (Gbadegesin et al., 2013), which is autosomal dominant as well. This evidence concerns the gene TNXB and vesicoureteral reflux 8.