MAPT and Alzheimer disease: Further, elevated oxidative stress (Weick et al., 2013; Dashinimaev et al., 2017; Sobol et al., 2019; Toshikawa et al., 2021), increased cell death, and pathological hallmarks of AD such as elevated amyloid-ß and hyperphosphorylated tau (Shi et al., 2012a; Dashinimaev et al., 2017; Toshikawa et al., 2021) have also been observed in DS iPSC-derived neurons (Table 1).