As NKX2.2 is a transcription factor that specifies oligodendrocyte lineage cells (Qi et al., 2001), and OLIG2+ progenitors can specify either interneurons or oligodendrocytes (Petryniak et al., 2007; Xu et al., 2019), these results could indicate the moleculr basis of impaired oligodendroglial fate at the expense of elevated interneuron specification in DS (Klein et al., 2021). The gene discussed is OLIG2; the disease is Dravet syndrome.