In fact, nearly every individual with DS presents pathological features of Alzheimer’s disease by the age of 40, including amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau (pTau) (Wisniewski et al., 1985; Head et al., 2016; Snyder et al., 2020). The gene discussed is MAPT; the disease is Dravet syndrome.