MECP2 and Encephalopathy: MECP2 (Methyl-CpG Binding Protein 2) is a Protein Coding gene. Diseases associated with MECP2 include Rett Syndrome and Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations. Among its related pathways are Ectoderm differentiation and Transcriptional Regulation by MECP2. Gene Ontology (GO) annotations related to this gene include RNA binding and chromatin binding. An important paralog of this gene is MBD4