ITGB3 and Stroke: Eight of these 20 genes have been reported to be associated with IS, including ITGB3, CDKN1A, ZFHX3, CREBBP, MECP2, RUNX1, BRD4, and FOXO3. Maguire et al. demonstrated that the ITGB3 (GPIIIa) variant (rs5918) is associated with functional outcomes in stroke survivors (Maguire et al., 2011).