CD8A and neoplasm: CD8 T cells and natural killer cells are involved in immune homeostasis and in the regulation of autoimmune reactivity (Valipour et al., 2019; Guillerey, 2020; Lees, 2020), while M1 macrophages were previously thought to have anti-tumor effects (Boutilier and Elsawa, 2021; Gunassekaran et al., 2021).