Another approach was presented to detect multiple breast cancer cell biomarkers including CD63, HER2, and EpCAM using Hydrophobic Plasmonic Nanoacorn Array (HANA) aptasensor that was synthesized by etching hydrophilic patches array on the surface of a hydrophobic plasmonic substrate to improve the reproducibility and reduce the nonspecific binding. The gene discussed is ERBB2; the disease is breast cancer.