Another approach was presented to detect multiple breast cancer cell biomarkers including CD63, HER2, and EpCAM using Hydrophobic Plasmonic Nanoacorn Array (HANA) aptasensor that was synthesized by etching hydrophilic patches array on the surface of a hydrophobic plasmonic substrate to improve the reproducibility and reduce the nonspecific binding. This evidence concerns the gene EPCAM and breast cancer.