OTOS and deafness: Thiopurine methyltransferase (TPMT), glutathione-S-transferase pi (GSTP1), cation transporters solute carrier family 22 member 2 (SLC22A2), and numerous deafness-related genes (otospiralin OTOS) have been observed to be associated with cisplatin ototoxicity in some genetics studies (Langer et al., 2020).