TCF7L2 and malignant colon neoplasm: While VTI1A::TCF7L2 was not enriched for detection in tumors vs. normal, only those fusions in colon cancer were highly expressed (>0.15 FFPM), whereas other tumor and normal instances were lowly expressed (<0.05 FFPM; many at the limit of detection; Figure S8E), supported by a single split read defining the fusion breakpoint (Table S4).