We readily identified known cancer fusions included in the COSMIC fusion collection34,35 (“COSMIC fusions,” Figure 4A) according to known disease associations and prevalence, such as TMPRSS2::ERG identified in roughly half of prostate cancers,3 FGFR3::TACC3 in glioblastoma,36 and PML::RARA in the acute promyelocytic leukemia subtype of acute myeloid leukemia (AML).37 This evidence concerns the gene PML and acute myeloid leukemia.