Many of the 108 fusions (51 fusions = 47%) involve a known ALL driver as one or both partners,52 such as KMT2A (eight fusions); PAX5, ZNF384, and MLLT10 (five fusions each); and NUP98, TCF3, and ETV6 (four fusions each). This evidence concerns the gene TCF3 and acute lymphoblastic leukemia.