COSMIC fusion VTI1A::TCF7L2, originally identified as an oncogenic fusion in colorectal cancer,49 was most abundant in stomach, colon, and esophageal carcinoma samples but was also detected in seven individual GTEx normal samples (brain, whole blood, tibial nerve, tibial artery, prostate, and breast) (Table S4). Here, TCF7L2 is linked to carcinoma of esophagus.