MAPT and Alzheimer disease: In AD, pathological aggregation of tau may be initiated through regulated self-assembly of the core stress granule–associated RNA-binding proteins, such as TIA1, G3BP1 (Ras-GTPase–activating protein binding protein 1), TIAR (T-cell–restricted intracellular antigen 1), and TTP (Tristetraprolin), and TIA1 has been shown to interact and aggregate with hyper-phosphorylated tau in 8-month-old P301L mice (De Magis et al., 2019) (Figure 3D).