MYC and neoplasm: Therefore, many in vitro and in vivo experiments have proved that modifying or stabilizing G4 structures in promoter regions will reduce the expression of tumor-causing genes, such as VEGF (Dexheimer et al., 2006), KRAS (Siddiqui-Jain et al., 2002), BCL2 (Yang and Hurley, 2006), and MYC (Gonzalez and Hurley, 2010).