HNRNPH1 binds to the G-rich sequences and destabilizes the G4-RNA structures formed by EWSR1-exon 8 and mediates its exclusion from the oncogenic EWS-FL1 transcripts in Ewing sarcomas (Georgakopoulos-Soares et al., 2022). The gene discussed is EWSR1; the disease is Ewing sarcoma.