However, Cornelis et al noted that the risk of developing myocardial infarction was not obviated by filtering diterpenoids.27 Variations in CYP1A2 activity among coffee consumers determined the risk of cardiovascular disease, and because CYP1A2 does not metabolize anything else in filtered coffee other than caffeine, the investigators were led to believe that caffeine is the major component of filtered coffee that increases the risk of myocardial infarction. Here, CYP1A2 is linked to cardiovascular disorder.