According to studies, age [10], gender, marital status (single or divorced) [11], family history of diabetes [12-14], ≥5 years of diabetes duration [15-18,19-25], poor glycemic control [15], adherence to diet [16], physical inactivity [14-17], obesity [13,14], mixed medication [17], insulin therapy [19], and hypertension [4-6,8,12,25-27], were associated with the microvascular complications of diabetes. The gene discussed is INS; the disease is diabetes mellitus.