But it is important to highlight the fundamental role of the nutritional status in optimizing clinical and surgical outcomes, and in preventing postoperative infections and wound complications, as observed in another investigation that showed that albumin, prealbumin and transferring levels may be predictive of wound complications after total knee arthroplasty.21 In the present study, we used linear regression analysis to assess changes over time and highlighted the fundamental role of nutritional investigation.21 This evidence concerns the gene TTR and infection.