Genome-wide association studies (GWAS) have identified about 40 genetic susceptibility loci of Alzheimer’s disease, which are associated with multiple molecular pathways, such as Abeta, tau, immunity, and lipid processing (Jansen et al., 2019; Kunkle et al., 2019; Andrews et al., 2020; Wightman et al., 2021). Here, MAPT is linked to Alzheimer disease.