These patterns may persist all the time or be elicited in some occasions such as febrile state (as seen in case 1), hyperkalemia, hypokalemia, hypercalcemia, alcohol or cocaine intoxication, and the use of certain medications, including sodium channel blockers, vagotonic agents, α-adrenergic agonists, β-adrenergic blockers, heterocyclic antidepressants, and a combination of glucose and insulin, making the diagnosis much more difficult [12]. The gene discussed is INS; the disease is Hyperkalemia.