Shen et al. reported [50] that in a mouse model of diabetic nephropathy, activation of the TLR9-NF-κB axis mediated NLRP3 inflammasome expression, and knockdown TLR9 downregulated NLRP3 inflammasome expression and reduced inflammatory damage in mouse mesangial cells. This evidence concerns the gene NFKB1 and diabetic kidney disease.