The use of Bintrafusp Alfa, a bifunctional fusion protein that inhibits both TGF-β and PD-L1, was found to synergize effectively with local radiotherapy (RT) in a variety of mouse immunocooled tumor models to overcome immune escape, eliminate treatment resistance, and improve survival while attenuating radiotherapy-induced fibrosis [182]. The gene discussed is CD274; the disease is neoplasm.