Metabolic rearrangements in tumor cells enhance mitochondrial fatty acid oxidation (FAO), which can provide cellular energy in the form of ATP via catabolism in mitochondria, helping tumor cells to escape radiotherapy-induced death and upregulate CD47 transcription via citric-acid–acetyl-coenzyme-A–RelA, which further exerts immunosuppressive effects and protects radiotherapy-resistant GBM cells from macrophage attacks. Here, CD47 is linked to glioblastoma.