PTGDR and lung carcinoma: Zhang et al. demonstrated that the notch homologous protein 2 (NOTCH2), miR-296, and lncRNA AGAP2 antisense RNA 1 (AGAP2-AS1) axis can affect the development and radioresistance of lung cancer, and that the M2-macrophage-derived exosomal lncRNA AGAP2-AS1 reduces lung cancer radiosensitivity by lowering miR-296 and increasing NOTCH2 [239].