XYS is proven a safe and effective treatment or adjuvant therapy for depression [47], which could regulated necroptosis [8], alleviates hippocampal glutamate-induced toxicity [9], regulating autophagy in hypothalamic neuron [48], modulated the gut microbiota and regulating the NLRP3 inflammasome [49]. The gene discussed is NLRP3; the disease is depressive disorder.