IFNG and neoplasm: For example, GP Ib-IX-V complex on platelet surface could bind to integrin on circulating blood tumor cells through fibrinogen αvβ3 to further promote the distant metastasis of tumor [20, 21]; activation of platelets by TGF-β could inhibit the killing activity of NK cells [22]; platelets could also significantly repress T cell proliferation via GARP/TGF-β pathway, as well as blastogenesis and IFN-γ expression [23].